12/18/2023 0 Comments Dr ralph argenSurely pictures of different mouse hearts, genetically different or treated with different drugs, cannot be derived from the same large continuous image? Maybe a student did it, who left the lab long ago? Hopefully the rogue student did not take the raw data with them, the paper is from last year! Something inadvertent also happened in this paper from Prof Schermuly’s lab:Īkylbek Sydykov, Himal Luitel, Argen Mamazhakypov, Malgorzata Wygrecka, Kabita Pradhan, Oleg Pak, Aleksandar Petrovic, Baktybek Kojonazarov, Norbert Weissmann, Werner Seeger, Friedrich Grimminger, Hossein Ardeschir Ghofrani, Djuro Kosanovic, Ralph Theo Schermuly Genetic Deficiency and Pharmacological Stabilization of Mast Cells Ameliorate Pressure Overload-Induced Maladaptive Right Ventricular Remodeling in Mice International Journal of Molecular Sciences (2020) doi: 10.3390/ijms21239099 Surely the inset image was reused inadvertently between Figure 1 and Supplemental Figure 4, to stand for different mice in different experimental conditions, and also darkened inadvertently in the process. Remember that institute!įriederike Christine Weisel, Christina Kloepping, Alexandra Pichl, Akylbek Sydykov, Baktybek Kojonazarov, Jochen Wilhelm, Markus Roth, Karen Marie Ridge, Kazuei Igarashi, Kazuhiro Nishimura, Wolfgang Maison, Claudia Wackendorff, Walter Klepetko, Peter Jaksch, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly, Norbert Weissmann, Grazyna Kwapiszewska Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling Circulation (2014) doi: 10.1161/circulationaha.113.006402Ī paper with such names on it can never be faulty. Like in this study, done in collaboration with Grazyna Kwapiszewska, director of the Ludwig Boltzmann Institute for Lung Vascular Research in Graz, Austria, and many other important German and Austrian colleagues: Walter Klepetko (head of surgery clinic at MedUni Vienna), Friedrich Grimminger (described as “ intellectual high-performance athlete”), plus anotherpulmonology professor in Giessen, Norbert Weissmann, and finally, a very senior figure: Werner Seeger, Medical Director of the Giessen-Marburg university hospital and department head at the Max-Planck Institute for Heart and Lung Research in Bad Nauheim. So how to explain? Exactly: maybe a rogue student or nameless technician did it, and in any case, these inadvertent mistakes do not affect any of the conclusions! But then again, many of of Prof Schermuly’s co-authors are (like him!) very eminent men of German pulmonology and cardiology, and these high-ranking titans of medicine can never be associated with questionable research. Which of course could not have happened here, because Professor Schermuly is an upright and honest scientist, otherwise he wouldn’t have been appointed an investigator of his own papers. In medicine, it is common and often expected to strategically include many of your important colleagues as co-authors on our papers, a practice called gift authorships. Schermuly, Michaela Kuhn Endothelial actions of atrial natriuretic peptide prevent pulmonary hypertension in mice Basic Research in Cardiology (2016) doi: 10.1007/s0039-x Unfortunately, some lung images got duplicated there, too.įranziska Werner, Baktybek Kojonazarov, Birgit Gaßner, Marco Abeßer, Kai Schuh, Katharina Völker, Hideo A. The next study was done in collaboration with Michaela Kuhn, pharmacology professor at the University of Würzburg. This paper was, like several others discussed here, done in collaboration with his Giessen colleague and fellow pulmonology professor, Ardeschir Ghofrani. Michaela Lang, Baktybek Kojonazarov, Xia Tian, Anuar Kalymbetov, Norbert Weissmann, Friedrich Grimminger, Axel Kretschmer, Johannes-Peter Stasch, Werner Seeger, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats PLoS ONE (2012) doi: 10.1371/journal.pone.0043433 Probably accidentally, where the image was also accidentally zoomed in the process of accidental duplication. An image was clearly duplicated, showing the lung of a different rat treated differently. Here a 9-year-old study from Prof Schermuly’s lab, one out of currently 19 recorded on PubPeer. Corrections were announced, and apparently there is nothing else for the Giessen University Ombudsman to do while Inspector Schermuly investigates! More recently, the pulmonologist was appointed by his university’s Ombudsman as a crime scene detective, to figure out how the image data in some of his paper got manipulated. Professor Ralph Schermuly is a specialist for lung hypertension at the Justus-Liebig-University Giessen in Germany, author of ~300 “from bench to bedside” papers and owner of an h-index of 70 ( in 2019).
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